Table 3. The 50 most significant GO terms.
| A: RVO versus control | |
| ID | Description |
| GO:0001525 | angiogenesis |
| GO:0045765 | regulation of angiogenesis |
| GO:1901342 | regulation of vasculature development |
| GO:0009611 | response to wounding |
| GO:0045766 | positive regulation of angiogenesis |
| GO:1904018 | positive regulation of vasculature development |
| GO:0060326 | cell chemotaxis |
| GO:0042060 | wound healing |
| GO:0030593 | neutrophil chemotaxis |
| GO:0050900 | leukocyte migration |
| GO:1990266 | neutrophil migration |
| GO:0030595 | leukocyte chemotaxis |
| GO:0071621 | granulocyte chemotaxis |
| GO:0048608 | reproductive structure development |
| GO:0061458 | reproductive system development |
| GO:0032103 | positive regulation of response to external stimulus |
| GO:0097530 | granulocyte migration |
| GO:0097529 | myeloid leukocyte migration |
| GO:0050729 | positive regulation of inflammatory response |
| GO:0070098 | chemokine-mediated signaling pathway |
| GO:0002548 | monocyte chemotaxis |
| GO:0002687 | positive regulation of leukocyte migration |
| GO:0070372 | regulation of ERK1 and ERK2 cascade |
| GO:0070371 | ERK1 and ERK2 cascade |
| GO:0071347 | cellular response to interleukin-1 |
| GO:0071674 | mononuclear cell migration |
| GO:0031349 | positive regulation of defense response |
| GO:0001890 | placenta development |
| GO:0002685 | regulation of leukocyte migration |
| GO:0030335 | positive regulation of cell migration |
| GO:2000147 | positive regulation of cell motility |
| GO:0002690 | positive regulation of leukocyte chemotaxis |
| GO:0051272 | positive regulation of cellular component movement |
| GO:0040017 | positive regulation of locomotion |
| GO:2001233 | regulation of apoptotic signaling pathway |
| GO:0070555 | response to interleukin-1 |
| GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway |
| GO:0002688 | regulation of leukocyte chemotaxis |
| GO:2001234 | negative regulation of apoptotic signaling pathway |
| GO:0048245 | eosinophil chemotaxis |
| GO:2001236 | regulation of extrinsic apoptotic signaling pathway |
| GO:0031099 | regeneration |
| GO:0097191 | extrinsic apoptotic signaling pathway |
| GO:0019221 | cytokine-mediated signaling pathway |
| GO:0050679 | positive regulation of epithelial cell proliferation |
| GO:0071345 | cellular response to cytokine stimulus |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| GO:0072216 | positive regulation of metanephros development |
| GO:0050878 | regulation of body fluid levels |
| GO:0050921 | positive regulation of chemotaxis |
| B: RVO versus untreated | |
| ID | Description |
| GO:0071345 | cellular response to cytokine stimulus |
| GO:0050900 | leukocyte migration |
| GO:0030335 | positive regulation of cell migration |
| GO:0051272 | positive regulation of cellular component movement |
| GO:2000147 | positive regulation of cell motility |
| GO:0040017 | positive regulation of locomotion |
| GO:0060326 | cell chemotaxis |
| GO:0001525 | angiogenesis |
| GO:0032103 | positive regulation of response to external stimulus |
| GO:0097529 | myeloid leukocyte migration |
| GO:0030595 | leukocyte chemotaxis |
| GO:0019221 | cytokine-mediated signaling pathway |
| GO:0031349 | positive regulation of defense response |
| GO:0002685 | regulation of leukocyte migration |
| GO:0001819 | positive regulation of cytokine production |
| GO:0002237 | response to molecule of bacterial origin |
| GO:0050727 | regulation of inflammatory response |
| GO:0002687 | positive regulation of leukocyte migration |
| GO:0045765 | regulation of angiogenesis |
| GO:0071621 | granulocyte chemotaxis |
| GO:0009611 | response to wounding |
| GO:1901342 | regulation of vasculature development |
| GO:0050778 | positive regulation of immune response |
| GO:0032496 | response to lipopolysaccharide |
| GO:0097530 | granulocyte migration |
| GO:0045785 | positive regulation of cell adhesion |
| GO:0002443 | leukocyte mediated immunity |
| GO:0002460 | adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| GO:0002250 | adaptive immune response |
| GO:1903706 | regulation of hemopoiesis |
| GO:0070371 | ERK1 and ERK2 cascade |
| GO:0002683 | negative regulation of immune system process |
| GO:0030593 | neutrophil chemotaxis |
| GO:0034341 | response to interferon-gamma |
| GO:0050920 | regulation of chemotaxis |
| GO:1990266 | neutrophil migration |
| GO:0007159 | leukocyte cell-cell adhesion |
| GO:0042060 | wound healing |
| GO:0045088 | regulation of innate immune response |
| GO:0070663 | regulation of leukocyte proliferation |
| GO:0043410 | positive regulation of MAPK cascade |
| GO:1902105 | regulation of leukocyte differentiation |
| GO:0050679 | positive regulation of epithelial cell proliferation |
| GO:0050921 | positive regulation of chemotaxis |
| GO:0032944 | regulation of mononuclear cell proliferation |
| GO:0070372 | regulation of ERK1 and ERK2 cascade |
| GO:0002690 | positive regulation of leukocyte chemotaxis |
| GO:0050670 | regulation of lymphocyte proliferation |
| GO:0050730 | regulation of peptidyl-tyrosine phosphorylation |
| GO:0002688 | regulation of leukocyte chemotaxis |
GO analysis using genes with fold change > 3 and pAdjust < 0.01. The 50 most significant GO groups are presented and ordered by significance. GO groups related to angiogenesis are labeled in italics while those related to inflammation are labeled in bold. Note that a group of GO terms related to angiogenesis are highly significant in the comparison of RVO versus controls while the comparison of RVO versus untreated shows almost exclusively GO terms related to inflammation. The first GO group related to hypoxia was found at positions 412 and 468, respectively.