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. Author manuscript; available in PMC: 2018 Mar 12.
Published in final edited form as: Nature. 2017 May 10;545(7654):317–322. doi: 10.1038/nature22070

Extended Data Figure 4. ‘Phylogenetic age’ of human GPCRs and Gα proteins.

Extended Data Figure 4

a, Estimation of the ‘phylogenetic age’ of human GPCRs and G proteins by identifying the most distant one-to-one orthologs (dark grey) or any ortholog (light grey) from 215 organisms in the OMA (Orthologous MAtrix) database. The ‘phylogenetic age’ was determined by the branching times of human and the oldest organisms that share either a 1-1 ortholog or any ortholog (one-many or many-one or many-many) with the human gene (Methods). The classification of GPCRs follows the IUPHAR receptor classification. b, Complete table of the GPCR and G protein repertoire and the phylogenetic ‘overlap’ of the protein repertoires. Jaccard Similarity Index (Methods) for the GPCR and G protein repertoires in the 12 completely sequenced genomes from the different eukaryotic lineages. The subscript U and S for organisms A and B refer to the number of unique and shared genes, respectively.