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a, Number of GPCRs with distinct primary signal transduction (G protein-coupling) for each GPCR family as annotated in the IUPHAR/BPS Guide to Pharmacology database (GtoPdb). Only ‘primary transduction’, as defined by the database, is shown here. Note that Fig. 1c and Fig. 1d show both primary and secondary coupling. b, Number of GPCRs with distinct primary signal transduction properties grouped by GPCR class.
