Table 4.

Statistical ANOVA of the responses (Y₁ to Y₅) results

Factors	Particle size (Y1), μm		PDI (Y2)		Zeta potential (Y3), mV		Entrapment efficiency (Y4), %		Cumulative release (Y5), %
	Estimate	p-value	Estimate	p-value	Estimate	p-value	Estimate	p-value	Estimate	p-value
X1	−15.15	0.6833	0.414667	0.0015*	0.825	0.4496	60.3233	0.0001*	67.16	0.0003*
X2	−164.375	0.0054*	0.263	0.1376	−2.9	0.0345*	9.23	0.9289	−13.1275	0.1599
X3	−212.575	0.0018*	0.07375	0.5358	11.725	0.0001*	0.08	0.1810	−2.495	0.0219*
X1X1	40.4917	0.4677	−0.02775	0.2918	−0.86667	0.5838	1.325	0.0030*	−4.9625	0.3983
X1X2	36.4	0.4954	−0.07241	0.2438	−0.75	0.6207	6.74167	0.0730	2.055	0.6866
X1X3	19.7	0.7072	0.078	0.8470	−3.9	0.0408*	−2.73	0.0794	−0.915	0.6290
X2X2	15.4417	0.7766	−0.012	0.7020	0.283333	0.8558	−2.65	0.0347*	1.1	0.3785
X2X3	23.75	0.6518	−0.02491	0.2742	−1.75	0.2735	3.61167	0.6291	2.15	0.7418
X3X3	26.5417	0.6286	0.0725	0.7456	8.03333	0.0029*	−0.62	0.0390*	0.745	0.5083
R2 %	92.41		90.60		97.36		97.24		94.83
Adj-R2	78.74		73.69		92.61		92.27		85.53
SEE	49.53		0.06		1.42		1.21		2.14
MAE	24.26		0.029		0.73		0.59		1.04

Note:

^*Significant effect of factors on individual responses.

Abbreviations: ANOVA, analysis of variance; PDI, polydispersity index; X₁, lipid concentration; X₂, surfactant concentration; X₃, cosurfactant concentration; R², R-squared; Adj-R², adjusted R-squared; SEE, standard error of estimate; MAE, mean absolute error.