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. 2018 Mar 7;11:1305–1314. doi: 10.2147/OTT.S156818

Table 3.

Univariate analysis of prognostic factors in ESCC with respect to DFS and OS

Univariate analysis Disease-free survival
Overall survival
HR (95% CI) p-value OS 95% CI p-value
Gender 1.270 (0.715–2.257) 0.415 1.311 (0.718–2.395) 0.378
Age 0.868 (0.539–1.399) 0.562 1.032 (0.616–1.727) 0.906
Location
 Upper Ref 0.148 Ref 0.278
 Middle 1.992 (0.963–4.118) 0.063 1.863 (0.845–4.107) 0.123
 Low 1.128 (0.647–1.966) 0.671 1.136 (0.623–2.07) 0.678
Length 1.196 (0.743–1.928) 0.461 1.484 (0.886–2.486) 0.133
Differentiation grade
 High Ref 0.396 Ref 0.333
 Middle 0.662 (0.341–1.284) 0.222 0.637 (0.328–1.236) 0.182
 Low 0.974 (0.562–1.690) 0.926 0.971 (0.560–1.684) 0.916
T stage (1, 2 vs 3, 4) 1.736 (1.034–2.914) 0.037 2.526 (1.380–4.622) 0.003
Lymph nodes 2.438 (1.509–3.938) <0.001 2.861 (1.697–4.823) <0.001
pTNM (I, II vs III, IV) 2.288 (1.416–3.697) 0.001 2.650 (1.576–4.456) <0.001
IKBKE expression 1.804 (1.076–3.027) 0.023 2.118 (1.189–3.773) 0.009

Note: Values in bold signify p<0.05, considered significant.

Abbreviations: CI, confidence interval; ESCC, esophageal squamous cell carcinoma; DFS, disease-free survival; HR, hazard ratio; OS, overall survival; Ref, reference; T, tumor; pTNM, pathological tumor node metastasis; IKBKE, inhibitor of NF-κB kinase epsilon.