Table 3.
Univariate analysis of prognostic factors in ESCC with respect to DFS and OS
| Univariate analysis | Disease-free survival
|
Overall survival
|
||
|---|---|---|---|---|
| HR (95% CI) | p-value | OS 95% CI | p-value | |
| Gender | 1.270 (0.715–2.257) | 0.415 | 1.311 (0.718–2.395) | 0.378 |
| Age | 0.868 (0.539–1.399) | 0.562 | 1.032 (0.616–1.727) | 0.906 |
| Location | ||||
| Upper | Ref | 0.148 | Ref | 0.278 |
| Middle | 1.992 (0.963–4.118) | 0.063 | 1.863 (0.845–4.107) | 0.123 |
| Low | 1.128 (0.647–1.966) | 0.671 | 1.136 (0.623–2.07) | 0.678 |
| Length | 1.196 (0.743–1.928) | 0.461 | 1.484 (0.886–2.486) | 0.133 |
| Differentiation grade | ||||
| High | Ref | 0.396 | Ref | 0.333 |
| Middle | 0.662 (0.341–1.284) | 0.222 | 0.637 (0.328–1.236) | 0.182 |
| Low | 0.974 (0.562–1.690) | 0.926 | 0.971 (0.560–1.684) | 0.916 |
| T stage (1, 2 vs 3, 4) | 1.736 (1.034–2.914) | 0.037 | 2.526 (1.380–4.622) | 0.003 |
| Lymph nodes | 2.438 (1.509–3.938) | <0.001 | 2.861 (1.697–4.823) | <0.001 |
| pTNM (I, II vs III, IV) | 2.288 (1.416–3.697) | 0.001 | 2.650 (1.576–4.456) | <0.001 |
| IKBKE expression | 1.804 (1.076–3.027) | 0.023 | 2.118 (1.189–3.773) | 0.009 |
Note: Values in bold signify p<0.05, considered significant.
Abbreviations: CI, confidence interval; ESCC, esophageal squamous cell carcinoma; DFS, disease-free survival; HR, hazard ratio; OS, overall survival; Ref, reference; T, tumor; pTNM, pathological tumor node metastasis; IKBKE, inhibitor of NF-κB kinase epsilon.