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. 2018 Mar 12;13(3):e0193943. doi: 10.1371/journal.pone.0193943

Table 1. Differentially expressed proteases in the biopsy supernatants of patients with IBS, UC, and controls.

        IBS vs. HC UC vs. HC IBS vs. UC
UniProt ID_HUMAN Name Localization Function log10 ratio P value log10 ratio P value log10 ratio P value
1. Q96QL8 Elastase 3A Extracellular Serine type endopeptidase with some elastolytic action, digestive function, intestinal cholesterol metabolism 0.63 0.026 0.22 0.870 0.41 0.025
2. A8MTQ9 Chymotrypsin-C Extracellular Serine type endopeptidase (pancreatic), some elastolytic action, chymotrypsin-like function, activation and degradation of trypsinogens and procarboxypeptidases 0.60 0.014 0.21 0.977 0.39 0.003
3. D3DPS0 Proteasome subunit beta type-2 Cytoplasm Multicatalytic threonine peptidase, caspase-,trypsin-, and chymotryosin-like activity, antigen processing and presentation via MHC class I 0.38 0.006 0.10 0.500 0.28 0.034
4. CO3 Complement C3 (unspecified isoform) Extracellular Molecule system including one/several serine proteases, activation of complement system, antimicrobial action. 0.29 0.016 -0.15 0.366 0.44 0.002
5. B4DJQ8 Cathepsin C Cytoplasm Cysteine endopeptidase controlling activation of serine proteases including elastase in inflammatory cells 1.18 0.001 1.10 0.007 0.07 0.493
6. B3KQK4 Cathepsin L1 Cytoplasm Cysteine endopeptidase with collagen and elastase as substrates; control of neutrophil elastase activity 0.51 0.005 0.29 0.309 0.22 0.081
7. DNPEP Aspartyl aminopeptidase Cytoplasm Intracellular protein and peptide metabolism 0.37 0.006 0.24 0.219 0.14 0.276
8. D3DW86 Proteasome subunit alpha type-4 Cytoplasm Multicatalytic threonine peptidase, immune defense, host-virus interaction 0.16 0.017 0.05 0.133 0.11 0.113
9. B2R7F8 Plasminogen Extracellular Serine type endopeptidase; cell surface; precursor of plasmin; pro inflammatory; immune defense 0.27 0.450 -1.33 0.073 1.60 0.006
10. CO3 Complement C3 Extracellular Molecule system including one/several serine proteases, activation of complement system, antimicrobial action. -0.10 0.823 -1.53 0.014 1.43 0.004
11. Q5U000 Cathepsin Z Cytoplasm Cysteine carboxypeptidase with broad specificity, immune processes -0.55 0.013 -0.22 0.034 -0.33 0.569
12. B2CIS9 Caspase 14 Cytoplasm Apoptosis-related cysteine peptidase -0.49 0.006 -0.18 0.091 -0.31 0.086
13. Q6IAT9 Proteasome subunit beta type-6 Cytoplasm Multicatalytic threonine peptidase, ATP-dependent proteolytic activity, caspase-like activity, immune defense -0.40 0.019 -0.10 0.107 -0.31 0.221
14. Q5QNR8 Proteasome subunit beta type-8 Cytoplasm Multicatalytic threonine peptidase, ATP-dependent proteolytic activity, immune defense, facilitates apoptosis -0.28 0.007 -0.16 0.043 -0.12 0.315
15. A8K071 X-prolyl aminopeptidase 1 Cytoplasm Metalloaminopeptidase; degradation of tachykinins, neuropeptides, and peptide hormones -0.62 0.016 -0.28 0.640 -0.35 0.037
16. A8K6H1 Endoplasmic reticulum aminopeptidase 1 Extracellular Zinc metallopeptidase, ubiquitous, immune defense, presentation of MHC class I presentation -0.26 0.046 0.15 0.519 -0.41 0.012
17. Q6IBC3 Cathepsin H Cytoplasm Cysteine endo-and exopeptidase, enkephalin and galanin neurotransmitter production -0.31 0.094 0.14 0.338 -0.44 0.020

P values for the F-test between all three groups were < 0.036; UniProt ID: universal protein database identification number: log10 ratio: differences in the log10 protein abundance; listed are those peptidases showing a significant difference between each of two study group

1–4 higher abundance in IBS versus HC and UC. 5 higher abundance in IBS versus HC and UC versus HC. 6–8 higher abundance only in IBS versus HC. 9–10 higher abundance in IBS versus UC. 11–14 lower abundance in IBS versus HC. 15–16 lower abundance in IBS versus HC and UC. 17 lower abundance in IBS versus UC. Data on function from Uniprot