Table 2.

Estimated mean outcomes.

Outcome measures	n	Adjusted means	Baseline–adjusted mean changes			Mean differences between groups at 6-month follow-up
		Baseline	Discharge	2 months	6 months	ITT analysis
		Mean (95% CI)	Mean (95% CI)	Mean (95% CI)	Mean (95% CI)	Mean (95% CI)	p value
FAMSa (Score 0–176)
Intervention	209	115.9 (111.0, 120.8)	12.6 (10.0, 15.2)	3.0 (0.5, 5.3)	0.6 (–2.1, 3.5)	1.6 (–1.4, 4.7)	0.232
Control	204	115.1 (110.0, 120.4)			–1.0 (–3.5, 1.6)	Ref.
MSIS-29 Physicala (Score 0–1001)
Intervention	209	40.8 (37.0, 44.6)	–12.0 (–14.1, –10.2)		–0.2 (–3.0, 2.3)	–0.6 (–3.0, 1.8)	0.640
Control	204	41.0 (37.1, 45.1)			0.4 (–2.1, 2.8)	Ref.
MSIS-29 Psychologicala (Score 0–100b)
Intervention	209	31.8 (27.9, 35.2)	–9.7 (–11.6, –7.9)		–1.2 (–3.8, 1.2)	–2.7 (–5.6, –0.1)	0.046
Control	204	29.8 (25.7, 33.3)			1.5 (–0.7, 3.6)	Ref.
15D Index (Score 0.106–1.000)
Intervention	209	0.771 (0.754, 0.789)			0.011 (–0.007, 0.027)	0.017 (0.005, 0.030)	0.008
Control	204	0.777 (0.762, 0.794)			–0.006 (–0.023, 0.008)	Ref.
EQ-5D-5L Index (Score −0.624 to −1.000)
Intervention	209	0.638 (0.606, 0.669)			–0.032 (–0.070, 0.001)	0.006 (–0.015, 0.028)	0.596
Control	204	0.638 (0.605, 0.669)			–0.038 (–0.075, –0.002)	Ref.
EQ-VAS (Score 0–100)
Intervention	173	60.4 (56.7, 64.1)	9.7 (7.1, 12.4)		3.8 (–0.1, 7.1)	2.5 (–1.1, 5.9)	0.112
Control	165	62.9 (58.9, 66.6)			1.2 (–2.5, 4.8)	Ref.
Factor 1
Intervention	209	0.064 (–0.147, 0.264)			0.063 (–0.044, 0.187)	0.116 (0.003, 0.229)	0.039
Control	204	0.130 (–0.068, 0.339)			–0.053 (–0.145, 0.059)	Ref.
Factor 2
Intervention	209	–0.161 (–0.308, –0.010)			–0.053 (–0.186, 0.063)	0.035 (–0.058, 0.139)	0.473
Control	204	–0.189 (–0.342, –0.037)			–0.089 (–0.206, 0.030)	Ref.

CI: confidence interval; FAMS: Functional Assessment in Multiple Sclerosis; ITT: Intention-To-Treat; MSIS-29: Multiple Sclerosis Impact Scale-29; EQ-VAS: EuroQol–visual analogue scales; EQ-5D-5L: EuroQoL 5 Dimensions 5 Levels.

^aPrimary outcome.

^bHigher score indicates greater impact.