Table 2.

Performance of liver stiffness measurement by transient elastography compared with liver biopsy in the detection of fibrosis in patients with NAFLD

Fibrosis stage	Cut-off value (kPa)	AUROC	Se	Sp	PPV	NPV	References
Stage ≥ 2	6.65	0.865	0.88	0.74	0.79	0.85	Yoneda M et al. Dig Liver Dis. 2008 [61]
Stage ≥ 3	9.8	0.904	0.85	0.81	0.64	0.93
Stage = 4	17.0	0.991	1.00	0.97	0.75	1.00
Stage ≥ 2	7.4	0.99	1	0.92	0.8	1	Nobili V et al. Hepatology. 2008 [65]
Stage ≥ 3	10.2	1.00	1.00	1.00	1.00	ND
Stage ≥ 2	7	0.84	0.79	0.76	0.7	0.84	Wong VW et al. Hepatology. 2010 [66]
Stage ≥ 3	8.7	0.93	0.84	0.83	0.6	0.95
Stage = 4	10.3	0.95	0.92	0.88	0.46	0.99
Stage ≥ 2	6.8	0.79	0.67	0.84	0.6	0.88	Lupsor M, et al. J Gastrointestin Liver Dis. 2010 [67]
Stage ≥ 3	10.4	0.98	1	0.97	0.71	1
Stage ≥ 2	7.25	0.795	0.69	0.7	ND	ND	Petta S et al. Aliment Pharmacol Ther. 2011 [58]
Stage ≥ 3	8.75	0.87	0.76	0.78	ND	ND
Stage ≥ 2	7	ND	0.76	ND	ND	ND	Gaia S, et al. J Hepatol. 2011 [68]
Stage ≥ 3	8	ND	0.65	ND	ND	ND
Stage = 4	10.5	ND	0.78	ND	ND	ND
Stage > 2	7.0 (6.2)	0.83 (0.80)	0.79 (0.73)	0.64 (0.66)	0.62 (0.54)	0.80 (0.75)	Wong VW et al. Am J Gastroenterol. 2012 [59]
Stage ≥ 3	8.7 (7.2)	0.87 (0.85)	0.83 (0.78)	0.84 (0.78)	0.58 (0.60)	0.93 (0.89)
Stage = 4	10.3 (7.9)	0.89 (0.91)	0.81 (0.88)	0.83 (0.76)	0.35 (0.35)	0.98 (0.98)
Stage > 2	7.6	0.81	73	78	48	91	Naveau S et al. Obes Surg. 2014 [59]
Stage = 3	7.6	0.85	100	74	27	100
Stage > 2	9.8 (6.2)	0.82	0.6 (0.9)	0.9 (0.45)	ND	ND	Cassinotto C et al. Hepatology 2016 [64]
Stage ≥ 3	12.5 (8.2)	0.86	0.57 (0.9)	0.9 (0.61)	ND	ND
Stage = 4	16.1 (9.5)	0.87	0.65 (0.92)	0.9 (0.62)	ND	ND
Stage > 2	11	0.82	0.65	0.89	0.88	0.66	Imajo K et al. Gastroenterology. 2016 [62]
Stage ≥ 3	11.4	0.88	0.86	0.84	0.75	0.92
Stage = 4	14	0.92	1	0.76	0.73	1
Stage > 2	6.9	0.86	0.79	0.82	0.66	0.9	Park CC et al. Gastroenterology. 2017 [63]
Stage ≥ 3	7.3	0.8	0.78	0.78	0.45	0.94
Stage = 4	6.9	0.69	0.63	0.66	0.15	0.95
Stage > 2	7.8	0.83	0.82	0.78	0.68	0.88	Chen J et al. Radiology 2017 [70]
Stage ≥ 3	7.6	0.84	0.84	0.64	0.43	0.92
Stage = 4	14.6	0.9	0.82	0.92	0.64	0.97

AUROC Area under the receiver-operating characteristic, NPV negative predictive value, PPV positive predictive value, Se sensitivity, Sp specificity