Table 4.
Design | MRI (Tesla) | Comparison with scoring system | Comparison with US elastography | Fibrosis stage | Cut-off value (kPa) | AUROC | Se | Sp | PPV | NPV | References |
---|---|---|---|---|---|---|---|---|---|---|---|
Retrospective, single center (N = 142) | 1.5 T | Yes | No | Stage ≥ 3 | 4.15 | 0.954 | 0.85 | 0.93 | ND | ND | Kim et al. Radiology. 2013 [94] |
Cross-sectional prospective, single center (N = 117) | 3.0 T | No | No | Stage ≥ 1 | 3.02 | 0.838 | 0.554 | 0.907 | 0.911 | 0.542 | Loomba et al. Hepatology. 2014 [96] |
Stage ≥ 2 | 3.58 | 0.856 | 0.657 | 0.915 | 0.767 | 0.862 | |||||
Stage ≥ 3 | 3.64 | 0.924 | 0.864 | 0.905 | 0.679 | 0.966 | |||||
Stage 4 | 4.67 | 0.894 | 0.800 | 0.944 | 0.571 | 0.981 | |||||
Individual participant data pooled analysis (N = 232) | 1.5 or 3.0 T | No | No | Stage ≥ 1 | 2.88 | 0.86 | 0.75 | 0.77 | ND | ND | Singh et al. Eur Radiol. 2016 [97] |
Stage ≥ 2 | 3.54 | 0.87 | 0.79 | 0.81 | ND | ND | |||||
Stage ≥ 3 | 3.77 | 0.90 | 0.83 | 0.86 | ND | ND | |||||
Stage 4 | 4.09 | 0.91 | 0.88 | 0.87 | ND | ND | |||||
Cross-sectional prospective, single center (N = 142) | 3.0 T | Yes | Yes vs. VCTE (M probe) | Stage ≥ 1 | 2.5 | 0.80 | 0.750 | 0.857 | 0.990 | 0.846 | Imajo et al. Gastroenterology. 2016 [62] |
Stage ≥ 2 | 3.4 | 0.89 | 0.873 | 0.850 | 0.884 | 0.836 | |||||
Stage ≥ 3 | 4.8 | 0.89 | 0.745 | 0.869 | 0.745 | 0.810 | |||||
Stage 4 | 6.7 | 0.97 | 0.909 | 0.945 | 0.588 | 0.992 | |||||
Cross-sectional, single center (N = 125) | 3.0 T | No | Yes vs. ARFI | Stage ≥ 1 | 2.99 | 0.799 | 0.583 | 0.906 | 0.894 | 0.615 | Cui et al. Hepatology. 2016 [81] |
Stage ≥ 2 | 3.62 | 0.885 | 0.667 | 0.957 | 0.846 | 0.889 | |||||
Stage ≥ 3 | 3.62 | 0.934 | 0.905 | 0.933 | 0.731 | 0.980 | |||||
Stage 4 | 4.15 | 0.882 | 0.889 | 0.914 | 0.444 | 0.991 | |||||
Cross-sectional prospective, single center (N = 100) | 3.0 T 2D (60 Hz) 3D (40 or 60 Hz) | No | No | Stage ≥ 1 (3D,40 Hz) | 1.77 | 0.848 | ND | ND | ND | ND | Loomba et al. Am J Gastroenterol. 2016 [95] |
Stage ≥ 2 (3D,40 Hz) | 2.38 | 0.856 | ND | ND | ND | ND | |||||
Stage ≥ 3 (3D,40 Hz) | 2.43 | 0.981 | 1.000 | 0.937 | 0.722 | 1.000 | |||||
Stage 4 (3D,40 Hz) | 3.21 | 0.993 | ND | ND | ND | ND | |||||
Cross-sectional prospective, single-center (N = 104) | 3.0 T | No | Yes vs. VCTE (M and XL probe) | Stage ≥ 1 | 2.65 | 0.82 | 0.765 | 0.791 | 0.813 | 0.739 | Park et al. Gastroenterology. 2017 [63] |
Stage ≥ 2 | 2.86 | 0.89 | 0.793 | 0.818 | 0.657 | 0.898 | |||||
Stage ≥ 3 | 2.99 | 0.87 | 0.778 | 0.803 | 0.483 | 0.938 | |||||
Stage 4 | 3.35 | 0.87 | 0.750 | 0.814 | 0.273 | 0.972 | |||||
Cross-sectional prospective, multi-center (N = 90), Child | 3.0 T | No | No | Stage ≥ 1 | 2.78 | 0.772 | 0.444 | 0.907 | 0.762 | 0.710 | Schwimmer et al. Hepatology. 2017 [98] |
AUROC Area under the receiver-operating characteristic, NPV negative predictive value, PPV positive predictive value, Se sensitivity, Sp specificity