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. 2017 Oct 19;2(20):e96540. doi: 10.1172/jci.insight.96540

Figure 5. In vivo effect of cinacalcet on plasma PTH, calcium, and phosphate concentrations of Gna11+/+, Gna11+/195G, and Gna11195G/195G mice.

Figure 5

(A–C) Plasma parathyroid hormone (PTH), (D–F) plasma albumin–adjusted calcium, and (G–I) plasma phosphate concentrations are shown at 0, 1, 2, 4, 6, and 24 hours following oral gavage administration of a single 30 mg/kg cinacalcet dose. Mean values for the respective groups are indicated by solid bars. n = 4–5 mice per study time point. Squares, males; circles, females. A Kruskal-Wallis test followed by Dunn’s test for nonparametric pairwise multiple comparisons were used for analysis of A–I. *P < 0.05, **P < 0.01 compared with respective untreated mice. $Untreated Gna11195G/195G mice were significantly (P < 0.05) hypercalcemic compared with untreated Gna11+/+ mice.