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. 2017 Oct 19;2(20):e95085. doi: 10.1172/jci.insight.95085

Figure 2. Exposure to maternal diabetes and Notch1 haploinsufficiency leads to increased incidence of ventricular septal defects.

Figure 2

(A) Breeding scheme demonstrating nondiabetic WT males crossed with nondiabetic (normoglycemic) and diabetic (hyperglycemic) Notch1+/– females. (B–E) Representative H&E-stained images showing the location of ventricular septal defects (*) in E13.5 WT and Notch1+/– hearts exposed to maternal diabetes as compared with nondiabetic WT and Notch1+/– controls. RA, right atrium, LA, left atrium; RV, right ventricle; LV, left ventricle. Scale bar: 200 μm.