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. 2018 Mar 1;12:1179069518759332. doi: 10.1177/1179069518759332

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© The Author(s) 2018

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 3. — Different models of neuronal subtype specification in developing neocortex. (A) In the common progenitor model, a single type of multipotent NSC sequentially gives rise to all neuronal subtypes during the course of development. Overtime, the fate potential of this NSC becomes increasingly restricted. Fate of the neuron is specified based on its birth date. (B) In the multiple progenitor model, multiple types of NSCs coexist and are, to some degree, predetermined to give rise to specific and restricted neuronal subtypes. Fate of the neuron is specified by the NSC type in this model. BP indicates basal progenitor; NSC, neural stem cell.