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. 2018 Feb 9;14:1744806918762031. doi: 10.1177/1744806918762031

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© The Author(s) 2018

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 3. — Attenuation of intracellular Ca²⁺ increase to capsaicin stimulation in neurons isolated from TRPV1 G564S^+/+ mice. (a) Basal intracellular Ca²⁺ concentrations (as F340/F380) in DRG neurons dissociated from TRPV1 G564S^+/+ mice and wild-type littermates (n = 9–11 neurons, ***p < 0.001 compared with corresponding control group, unpaired Student’s t test). (b, c) Intracellular Ca²⁺ responses to 1 μM (b) or 5 μM (c) capsaicin in DRG neurons dissociated from TRPV1 G564S^+/+ mice and wild-type littermates. Note the faster and more dramatic increase of Ca²⁺ signals in wild-type neurons. In (b) and (c), Fura-2 ratio was normalized to t0 in each group, n = 7–11 neurons, ***p < 0.001 compared with corresponding control groups, two-way ANOVA, followed by Bonferroni post hoc tests. TRPV: transient receptor potential vanilloid; WT: wild type.