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. 2018 Feb 9;14:1744806918762031. doi: 10.1177/1744806918762031

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© The Author(s) 2018

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 4. — Impaired behavioral responses of TRPV1 G564S^+/+ mice to capsaicin, heat, and inflammatory pain. (a) Total duration of capsaicin-induced nociceptive responses during a 5-min period (n = 8–9, ***p < 0.001, unpaired Student’s t test). (b) Latency to fall in the rotarod test was comparable between TRPV1 G564S^+/+ mice (n = 8) and wild-type littermates (n = 6). (c) Latency to paw withdrawal in the hot-plate test of TRPV1 G564S^+/+ mice (n = 8) and wild-type littermates (n = 5). Note the withdrawal latency of TRPV1 G564S^+/+ mice was always significantly higher than wild-type littermates. (d) Latency to tail withdrawal in the tail-flick test of TRPV1 G564S^+/+ mice (n = 8) and wild-type littermates (n = 5). Note the tail flick latency of TRPV1 G564S^+/+ mice was always significantly higher than wild-type littermates. (e) Change in paw withdrawal latency tested by the hot plate at 52.5°C after intraplantar injection of CFA (n = 5). Note the paw withdrawal latency of TRPV1 G564S^+/+ mice was always significantly higher than wildtype littermates. In (c–e), Error bars, SEM; ***p < 0.001 compared with corresponding control groups, two-way ANOVA, followed by Bonferroni post hoc tests, **p < 0.01, ***p < 0.001. TRPV: transient receptor potential vanilloid; WT: wild type.