Table 3.
Results of analyses comparing the total glioma group with the non-CNS control group
| Intention to treat | Per protocol | |||||
|---|---|---|---|---|---|---|
| Glioma total group | Non-CNS control group | P value, ES, 95% CI | Glioma total group | Non-CNS control group | P value, ES, 95% CI | |
| Depression (CES-D) M (SD) | ||||||
| Baseline |
N = 82 22.14 (6.1) |
N = 26 25.08 (6.6) |
N = 63 22.11 (5.9) |
N = 24 25.08 (6.7) |
||
| After intervention |
N = 42 19.52 (7.5) |
N = 13 20.31 (6.3) |
p = 0.267, ES = 0.300 95% CI = − 1.70 to 6.09 |
N = 38 19.82 (6.9) |
N = 13 20.31 (6.3) |
p = 0.272, ES = 0.401, 95% CI = − 1.75 to 6.18 |
| After 12 weeks |
N = 41 20.85 (8.5) |
N = 12 25.41 (7.1) |
p = 0.467, ES = 0.302, 95% CI = − 6.36 to 2.93 |
N = 38 20.42 (8.4) |
N = 12 25.42 (7.1) |
p = 0.418, ES = 0.218, 95% CI = − 6.66 to 2.78 |
| After 12 months |
N = 35 18.60 (9.3) |
N = 7 18.14 (7.0) |
p = 0.390, ES = 0.499, 95% CI = − 3.31 to 8.42 |
N = 33 17.85 (9.0) |
N = 7 18.14 (6.9) |
p = 0.447, ES = 0.433, 95% CI = − 3.76 to 8.00 |
| Fatigue (CIS) M (SD) | ||||||
| Baseline |
N = 82 91.76 (20.2) |
N = 26 96.85 (13.5) |
N = 63 93.48 (18.9) |
N = 24 96.75 (13.0) |
||
| After intervention |
N = 42 89.74 (24.9) |
N = 13 86.74 (18.1) |
p = 0.208, ES = 0.426, 95% CI = − 3.59 to 16.35 |
N = 38 91.02 (23.5) |
N = 13 86.69 (18.1) |
p = 0.241, ES = 0.430, 95% CI = − 4.06 to 16.00 |
| After 12 weeks |
N = 41 90.12 (27.2) |
N = 12 90.42 (15.2) |
p = 0.503, ES = 0.252, 95% CI = − 8.16 to 16.54 |
N = 38 88.53 (27.1) |
N = 12 90.42 (15.2) |
p = 0.716, ES = 0.078, 95% CI = − 10.12 to 14.69 |
| After 12 months |
N = 34 87.94 (24.2) |
N = 7 94.57 (23.7) |
p = 0.587, ES = 0.081, 95% CI = − 20.69 to 11.78 |
N = 32 86.19 (23.9) |
N = 7 94.57 (23.7) |
p = 0.438, ES = 0.289, 95% CI = − 22.60 to 9.86 |
| Health-related quality of life (SF-36 MCS) M (SD) | ||||||
| Baseline |
N = 82 35.27 (9.0) |
N = 26 29.73 (7.3) |
N = 63 34.94 (8.5) |
N = 24 29.58 (7.2) |
||
| After intervention |
N = 41 36.79 (10.2) |
N = 13 35.20 (8.3) |
p = 0.159, ES = 0.455, 95% CI = − 8.43 to 1.40 |
N = 37 36.53 (9.9) |
N = 13 35.20 (8.3) |
p = 0.201, ES = 0.489, 95% CI = − 8.10 to 1.72 |
| After 12 weeks |
N = 41 37.42 (10.2) |
N = 12 33.48 (13.0) |
p = 0.385, ES = 0.184, 95% CI = − 7.50 to 2.92 |
N = 38 37.92 (10.2) |
N = 12 33.48 (13.0) |
p = 0.478, ES = 0.112, 95% CI = − 7.26 to 3.42 |
| After 12 months |
N = 35 39.83 (9.2) |
N = 7 33.34 (10.4) |
p = 0.601, ES = 0.109, 95% CI = – 5.12 to 8.80 |
N = 33 40.24 (9.3) |
N = 7 33.34 (10.4) |
p = 0.545, ES = 0.187, 95% CI = − 4.89 to 9.19 |
| Health-related quality of life (SF-36 PCS) M (SD) | ||||||
| Baseline |
N = 82 47.46 (10.7) |
N = 26 44.44 (9.6) |
N = 63 47.13 (11.2) |
N = 24 44.52 (9.9) |
||
| After intervention |
N = 41 50.05 (10.7) |
N = 13 47.81 (11.7) |
p = 0.734, ES = 0.074, 95% CI = − 5.24 to 3.70 |
N = 37 50.06 (11.24) |
N = 13 47.81 (11.7) |
p = 0.822, ES = 0.033, 95% CI = − 4.93 to 3.92 |
| After 12 weeks |
N = 41 48.41 (9.9) |
N = 12 49.07 (11.4) |
p = 0.549, ES = 0.350, 95% CI= – 6.76 to 3.62 |
N = 38 48.66 (9.6) |
N = 12 49.07 (11.4) |
p = 0.662, ES = 0.276, 95% CI = − 6.80 to 4.35 |
| After 12 months |
N = 35 47.61 (11.3) |
N = 7 53.88 (7.9) |
p = 0.035*, ES = 0.883, 95% CI = − 13.08 to − 0.49 |
N = 33 48.32 (11.0) |
N = 7 53.86 (7.9) |
p = 0.053*, ES = 0.744, 95% CI = – 13.09 to 0.08 |
CES-D Center for Epidemiological Studies—Depression Scale, CIS Checklist Individual Strength, ES effect size, ITT intention to treat, PP per protocol, SF-36 MCS Short-Form 36 Health Survey Mental Component Summary, SF-36 PCS Short-Form 36 Health Survey Physical Component Summary
* p < 0.05