Table 2.
Excision volumes
| Study | Study type | Inclusion period | Comparison | BCS after NACT (vs. primary BCS) | Tumor diameter (mm) | pCR (%) | Volume measurement | Resection volume or weight | Peroperative localization | OPBS (%) | OCEBM evidence |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Boughey 2006 [25] | Prospective cohort (RCT comparing chemotherapy regimens) | 1998–2005 | NACT versus adjuvant chemotherapy | 162 (vs. 101) | Pre-NACT T1 = 20 mm vs. 15 mm (p = 0.0055)a T2 = 34.5 mm vs. 30 mm (p = 0.143)a |
NR | (4/3 π (l × w × h )) | T1: 98 vs. 111 cm3 (p = 0.51) T2: 113 vs. 213 cm3 (p = 0.0043) |
Wire palpation | NR | 3 |
| Komenaka 2011 [27] | Retrospective single-center cohort | 2002–2009 | NACT versus adjuvant chemotherapy | 38 (vs. 68) | Pre-NACT 46 mm vs. 33 mm |
NR | The product of the 3 diameters | 143.6 vs. 273.9 cm3 (p = 0.003) | NR | NR | 4 |
| Tiezzi 2008 [31] | Retrospective single-center cohort | 1990–2003 | NACT versus no-NACT | 88 (vs. 191) | 6 mm vs. 19 mm (p = 0.01)b | NR | 1 (4/3 π (l × w × h)) | 108 vs. 78 cm3 (p = 0.002) | NR | NR | 4 |
| Karanlik 2015 [28] | Retrospective single-center cohort | 2008–2011 | NACT versus no-NACT | 80 (vs. 116) | Pre-NACT 38.4 mm vs. 30.7 mma Post-NACT 17.3 mm vs. 31.2mmb |
37% | NR | 132.2 vs. 158.1 cm3 (p = 0.04) | Wire | NR | 4 |
| Volders 2016 [33] | Retrospective national database | 2012–2013 | NACT versus no-NACT | 626 (vs. 9276) | NR | 17% | (4/3 π (l × w × h )) | 50 vs. 46 cm3 | NR | NR | 4 |
| Peintiger 2006 [48] | Retrospective single-center cohort | 1987–2002 | 109 | Pre-NACT 35 mm | 100% | (4/3 π (l × w × h)) | 73.12 cm3 | NR | NR | 4 | |
| van Riet 2010 [47] | Prospective single-center cohort | 2003–2008 | 47 | Pre-NACT 34 mmaPost-NACT 8mma | 40% | NR | 107.25 cm3/ 38.61 g | I-125 seed | NR | 4 | |
| Espinosa 2011 [49] | Retrospective single-center cohort | 1999–2009 | Tattoo versus marker | 149; 118 vs. 31 | Pre-NACT 31 mm vs. 32 mma | 53% vs. 45% | (4/3 π (diameter3)). | 268 vs. 143 cm3 | Palpation Wire Ultrasound Tattoo |
NR | 4 |
| Donker 2013 [40] | Retrospective single-center cohort | 2007–2010 | ROLL versus I-125 seed | 154; 83 vs. 71 | NR | 38% | Weight | 53 g vs. 48 g | ROLL I-125 seed |
NR | 4 |
| Mazouni 2013 [39] | Retrospective single-center cohort | 2002–2010 | BCS versus OPBS | 259; 214 vs. 45 | NR | 24.3% vs. 22.2% | NR | 98 versus 180 cm3 (p < 0.0001) | NR | 17.4% | 4 |
| Ramos 2014 [42] | Retrospective single-center cohort | 2008–2012 | 58 | Pre-NACT 28.3 mma Post-NACT 11.7 mma | NR | Weight | 26.4 gram | IOUS | NR | 4 | |
| Janssen 2016 [20] | Retrospective single-center cohort | 2007–2014 | 401 | NR | 37.7% | Formula of a cube | 2008: 119.5 cm3 2014: 45.0 cm3 |
I-125 seed | NR | 4 | |
| Rubio 2016 [44] | Retrospective single-center cohort | 2008–2012 | IOUS versus Wire | 213; 145 vs. 69 | Pre-NACT 24.51 mm vs. 24.06 mma | 32.4% vs. 43.4% | (4/3 π (l × w × h )) | 54.18 vs. 43.72cm3 | IOUS Wire |
NR | 4 |
| Chauhan 2016 [45] | Prospective single-center cohort | 2012–2014 | BCS versus OPBS | 100; 43 vs. 57 | Pre-NACT 49 vs. 53mm Post-NACT23mm vs 44mm (p0.04) |
NR | l × w × h | 125.19 vs. 187.54 cm3 | NR | 57% | 4 |
| Carrara 2017 [50] | Retrospective single-center cohort | 2005–2012 | 98 | Pre-NACT 52 mm | 13.30% | Weight | 233 g | NR | 26,50% | 4 |
NR not reported, NACT neoadjuvant chemotherapy, IOUS intraoperative ultrasound, BCS breast-conserving surgery, OPBS oncoplastic breast surgery, ROLL radio occult lesion localization
aRadiological diameter
bPathological diameter