Fig. 4.

Raptor as a prognostic marker shows diverse outcomes depending on localization. a High intensity of raptor in the cytoplasm indicated a significantly worse prognosis. This was not evident during the first 5 years after randomization. For the group of patients that had no distant recurrences within the first 5 years, the raptor intensity in the cytoplasm had significant impact on the distant metastasis rate. All patients were included in the analysis. b High intensity of raptor in the cytoplasm tended to be significantly worse for systemically untreated patients. No difference was observed for the time periods before and after 5 years from randomization. c Low, medium, and high scores of raptor in the nucleus of all patients, p = 0.031. d Low, medium, and high scores of raptor in the nucleus of systemically untreated patients, p = 0.13