Table 1.
Correlations between raptor protein expression in the cytoplasm, intensity low and high, and in the nucleus, three graded scores of intensity and percentage positive nuclei low, medium, and high, with clinical and pathological variables
| Raptor in the cytoplasm | Raptor in the nucleus intensity score | ||||||
|---|---|---|---|---|---|---|---|
| Low | High | p (rs) | Low | Medium | High | p (rs) | |
| All | 368 (49) | 388 (51) | 238 (31) | 192 (25) | 326 (43) | ||
| No tamoxifen | 181 (49) | 187 (51) | 109 (30) | 103 (28) | 156 (42) | ||
| Tamoxifen | 187 (48) | 201 (52) | 0.079 (–) | 129 (33) | 89 (23) | 170 (44) | 0.78 (–) |
| Size <20 mm | 284 (50) | 284 (50) | 164 (29) | 131 (23) | 273 (48) | ||
| Size >20 mm | 75 (44) | 95 (56) | 0.18 (–) | 70 (41) | 53 (31) | 47 (28) | 0.00001 (−0.16) |
| NHG 1 | 66 (55) | 54 (45) | 25 (21) | 28 (23) | 67 (56) | ||
| NHG 2 | 183 (49) | 194 (51) | 112 (30) | 87 (23) | 178 (47) | ||
| NHG 3 | 61 (42) | 85 (58) | 0.031 (–) | 66 (45) | 47 (32) | 33 (21) | <0.00001 (−0.22) |
| ER negative | 70 (42) | 95 (58) | 73 (44) | 51 (31) | 41 (25) | ||
| ER positive | 288 (51) | 281 (49) | 0.064 (–) | 162 (28) | 132 (23) | 275 (48) | <0.00001 (0.18) |
| PgR negative | 152 (47) | 173 (53) | 132 (41) | 79 (24) | 114 (35) | ||
| PgR positive | 175 (51) | 169 (49) | 0.29 (–) | 86 (25) | 80 (23) | 178 (52) | <0.00001 (0.19) |
| HER2 negative | 312 (51) | 304 (49) | 192 (31) | 153 (25) | 271 (44) | ||
| HER2 positive | 30 (36) | 54 (64) | 0.010 (–) | 34 (40) | 24 (29) | 26 (31) | 0.024 (–) |
| pAKTs473 c low | 174 (62) | 108 (38) | 115 (41) | 67 (24) | 100 (35) | ||
| pAKTs473 c high | 179 (40) | 271 (60) | <0.00001 (0.21) | 115 (26) | 119 (26) | 216 (48) | 0.00002 (0.16) |
| pAKTs473 n low | 163 (52) | 148 (48) | 162 (52) | 81 (26) | 68 (22) | ||
| pAKTs473 n high | 190 (45) | 231 (55) | 0.051 (–) | 68 (16) | 105 (25) | 248 (59) | <0.00001 (0.42) |
| p-mTORs2448 low | 309 (48) | 330 (52) | 210 (33) | 166 (26) | 263 (41) | ||
| p-mTORs2448 high | 41 (45) | 50 (55) | 0.056 (–) | 19 (21) | 20 (22) | 52 (57) | 0.0032 (0.11) |
| pS6Kt389 c low | 178 (58) | 131 (42) | 101 (33) | 82 (27) | 126 (41) | ||
| pS6Kt389 c high | 174 (41) | 251 (59) | 0.00001 (0.16) | 128 (30) | 105 (25) | 192 (45) | 0.27 (–) |
| pS6Kt389 n low | 229 (51) | 222 (49) | 192 (43) | 121 (27) | 138 (31) | ||
| pS6Kt389 n high | 123 (44) | 159 (56) | 0.059 (–) | 37 (13) | 65 (23) | 180 (64) | <0.00001 (0.36) |
| pERs167 low | 292 (50) | 296 (50) | 214 (36) | 157 (27) | 217 (37) | ||
| pERs167 high | 73 (45) | 90 (55) | 0.27 (–) | 23 (14) | 34 (21) | 106 (65) | <0.00001 (0.24) |
| pERs305 low | 247 (52) | 225 (48) | 175 (37) | 134 (28) | 163 (35) | ||
| pERs305 high | 107 (41) | 153 (59) | 0.0038 (0.11) | 55 (21) | 53 (20) | 152 (58) | <0.00001 (0.23) |
| S6K1 c low | 335 (51) | 325 (49) | 207 (31) | 171 (26) | 282 (43) | ||
| S6K1 c high | 26 (31) | 57 (69) | 0.00084 (0.12) | 25 (30) | 20 (24) | 38 (46) | 0.66 (–) |
| S6K1 n low | 311 (50) | 307 (50) | 203 (33) | 162 (26) | 253 (41) | ||
| S6K1 n high | 50 (40) | 75 (60) | 0.035 (–) | 29 (23) | 29 (23) | 67 (54) | 0.0072 (0.10) |
| Cyclin D1 low | 240 (53) | 215 (47) | 165 (36) | 125 (27) | 165 (36) | ||
| Cyclin D1 high | 121 (44) | 152 (56) | 0.028 (–) | 65 (24) | 64 (23) | 144 (53) | 0.00001 (0.17) |
Pearson χ2 analysis was used for 2 × 2 correlations, and Spearman rank order analysis was used for 3 × 2 and 3 × 3 variable correlations. A p value <0.01 was considered significant. Spearman rank order correlation values (rs) are given in case of significance. Bold p values indicate a significant negative correlation and italic p values indicate a significant positive correlation