Table 1.
Design Parameters | Interpretation | |
---|---|---|
n | Training sample size | |
m | Total number of independent markers in genotyping panel | |
p 0, p 1 | Lower and upper P values to select markers into polygenic score | |
Genetic model parameters | ||
|
Variance in Y explained by genotypes G; chip heritability of Y | |
|
Variance in Y explained by environment X | |
|
Variance in X explained by genotypes G; chip heritability of X | |
ρ | Genetic (chip) correlation between X and Y | |
π0 | Proportion of markers with no effect on Y |