Table 2.

AUC for environmental score, polygenic score, and combined scores based on a genetic model matching results for CVD reported by Morris et al

	Environment	Polygenic	Unweighted Sum		Weighted Sum
N cases			ρ = 0.1	ρ = 0.4	ρ = 0.1	ρ = 0.4
63,746	0.635	0.536 (5× 10−8)	0.622 (5× 10−8)	0.621 (5 × 10−8)	0.623 (5 × 10−8)	0.622 (5 × 10−8)
63,746	0.635	0.666 (0.053)	0.693 (0.033)	0.688 (0.036)	0.701 (0.053)	0.693 (0.053)
∞	0.635	0.782	0.800	0.784	0.800	0.788

In parentheses, P‐value thresholds to select SNPs into polygenic score; N cases, number of cases in training sample with 2.05 controls per case as in CARDIoGRAMplusC4D.