Table 6.

NRI for a single‐risk threshold of 8%, continuous NRI and IDI for combined scores based on a genetic model matching results for breast cancer reported by Mavaddat et al

	8% Risk		Continuous NRI		IDI
N cases	Case	Control	Case	Control
33,673 (5 × 10−8)	0.119	− 0.046	0.286	0.015	0.008
33,673	0.303 (0.0034)	− 0.059 (0.89)	0.544 (0.0035)	0.029 (0.0035)	0.034 (0.0035)
∞	0.441	− 0.094	0.771	0.041	0.089

In parentheses, P‐value thresholds to select SNPs into polygenic score; N cases, number of cases in training sample with 0.99 controls per case as in the Breast Cancer Association Consortium. $\rho =0.4$, $R_{GX}^2=0.8$.