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. 2017 Dec 29;27(1):15–23. doi: 10.1007/s11248-017-0054-x

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 2 — Histochemical and immunohistochemical analyses of amyloid deposits in the small intestine of a 7.2-hMet30 mouse kept under CV conditions. Congo red-positive deposits were present in the lamina propria of the small intestine (a). These deposits showed apple green birefringence under polarized light (b). Amyloid deposits demonstrated positive reactions with anti-human TTR antibody in our immunohistochemical analysis (c). Immunohistochemical analysis suggested co-precipitation of HPX in TTR amyloid deposits (d), and the presence of Tf (e). Bars = 100 μm. (Color figure online)