Figure 7.
Gene Signatures of NK Cells and cDC1 Positively Correlate with Cancer Patient Survival
(A) Heatmap showing the ordered, z-transformed expression values for NK cell-specific genes in melanoma patients.
(B) Expression of NK cell signature genes for top and bottom quartiles of TCGA datasets.
(C) Prognostic value of the NK cell signature for overall survival of human cancer patients comparing top and bottom quartiles.
(D) Heatmap showing the ordered, z-transformed expression values for cDC1-specific genes in melanoma patients.
(E) Expression of cDC1 signature genes for top and bottom quartiles of indicated TCGA datasets.
(F and G) Prognostic value of the cDC1 gene signature (F) or of CLEC9A expression levels (G) for cancer patient overall survival comparing top and bottom quartiles.
(H) Hazard ration comparison of the cDC1 and a CD8 T cell signature as an indicator of overall survival.
The dotted line indicates a p value of 0.05. Data in (B) and (E) are represented as mean ± SD. p, p value; n, number of data points in the analysis.