Table 2.

Clinically meaningful outcomes in patients with NAFLD/NASH

Histological improvement in NASH

Steatosis

Inflammation

Hepatocyte ballooning

Fibrosis

Incident neoplasms

Hepatic cancer

Extra-hepatic cancer

Mortality/morbidity

All cause mortality/morbidity

Liver—related mortality/morbidity (LT)

Symptoms/QOL (patient reported outcome: PRO)

Hepatic failure (ascites, edema, jaundice, variceal hemorrhage, etc.)

QOL (physical health, mental health)

Labor productivity

Well-being

Economics

Lifetime medical cost