Fig. 16.

Simulations of the positive feedback model with cut-off in the phase plane spanned by the dimensionless concentrations of PRL in lactographs (x) and in plasma (y) (Left) and dimensionless PRL in plasma versus dimensionless time ($\mathit{\tau }$) (Right) for the same doses D of risperidone as in Fig. 13: D = 0.05, 0.1, 1 and 2 mg/kg. The drug PK is simulated using the PK model for iv dose of risperidone [34] (cf. Appendix A)