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. 2017 Sep 7;45(1):3–21. doi: 10.1007/s10928-017-9539-8

Fig. 9.

Fig. 9

Graphs show the amount versus time courses during a constant-rate infusion over 103 and 105 h of compound in the second compartment (A2(t) (blue)), in the third (A3(t) (red)) and the fourth (A4(t) (green)). The left panel shows how over a period of about 500 h A2 climbs to an intermediate steady state and the right panel shows how A2 slowly climbs over a much longer period (5×104 h) to its final steady state A2,ss. Details about the evolution of A3 and A4 are shown in Fig. 10 (Color figure online)