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. Author manuscript; available in PMC: 2018 Mar 12.
Published in final edited form as: J Thromb Haemost. 2015 Oct 23;13(11):1949–1959. doi: 10.1111/jth.13145

Figure 2. Spatio-temporal regulation of platelet activation following vascular injury.

Figure 2

A) Photomicrograph shows platelet accumulation, activation and fibrin deposition following laser-induced injury in a mouse cremaster arteriole. Note the leakage of RBCs into the extravascular space as a result of the injury, and the spatial localization of P-selectin positive platelets adjacent to the site of injury. Scale bar is 10 μm. B) Graph depicts typical kinetics of platelet accumulation, activation and fibrin deposition following laser-induced injury in cremaster arterioles of C57Bl/6 mice. Platelet accumulation is shown in red (left axis), P-selectin in green and fibrin in blue (right axis). Values are mean±SEM for n=27 thrombi.