TABLE 5.
Serum IP-10 Levels after first infusion of rhIL-18
| rhIL-18 Dose Cohort | Serum IP-10 Levels (pg/mL; mean ± SD) (P values from t-test comparing post-dose to baseline values) | |||
|---|---|---|---|---|
| Baseline (Pre-dose) | 4 hours after rhIL-18 dose | 6 hours after rhIL-18 dose | Week 2, Day 1 | |
| 3 μg/kg (N = 3) | 145 ± 59 | 500 ± 0 (P = 0.0090) | 468 ± 55 (P = 0.0022) | 203 ± 51 (P = 0.2675) |
| 10 μg/kg (N = 3) | 94 ± 54 | 500 ± 0 (P = 0.0057) | 500 ± 0 (P = 0.0057) | 188 ± 23 (P = 0.0499) |
| 30 μg/kg (N = 3) | 110 ± 45 | 500 ± 0 (P = 0.0044) | 500 ± 0 (P = 0.0044) | 142 ± 27 (P = 0.3544) |