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. Author manuscript; available in PMC: 2019 Mar 28.
Published in final edited form as: J Control Release. 2018 Jan 31;274:69–80. doi: 10.1016/j.jconrel.2018.01.020

Figure 4. Grafts containing atRA exhibit an altered distribution of intimal formation.

Figure 4

(A) Schematic of sample processing, and representative harvested sample. (B–E) Quantification of intimal area at all 4 regions: proximal artery, proximal graft, distal graft, and distal artery for (B) ePTFE, (C) POC-ePTFE, (D) atRA-ePTFE and (E) atRA-POC-ePTFE grafts. Data expressed as mean ± SE, represents 5–6 sections at each location from each rat (n=6–7/treatment group), analysis via one-way ANOVA. *P < 0.05 and **P < 0.05 versus PA and DA; ↑P < 0.05 versus PA, DG and DA; ↑↑P < 0.05 versus DA. PA: proximal artery, PG: proximal graft, DG: distal graft, DA: distal artery, ePTFE: extended polytetrafluroethylene, POC-ePTFE: poly(1,8 octamethylene citrate) ePTFE, atRA-ePTFE: all-trans retinoic acid-coated ePTFE, and atRA-POC-ePTFE: all-trans retinoic acid- poly(1,8 octamethylene citrate) ePTFE.