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. 2018 Mar 12;8:4357. doi: 10.1038/s41598-018-22711-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic workflow of processing procedure applied to data and the six measures obtained. After image post-processing, several fitting procedures were applied to ²³Na-MRI data derived from 10 ROIs (examples shown include the caudate, putamen, pallidum and corpus callosum). Fitting included: (a) a biexponential model to obtain estimates of the magnetization (M0_SF, M0_LF) apparent from the signal fractions associated with short and long T₂* components from in vivo ROIs; (b) a monoexponential model to obtain estimates of M0 for each reference tube and (c) a linear model of the relationship between M0 and known reference concentrations. The six output parameters and their derivation are marked: two T₂* components (dashed outline), a Na concentration for each component (double outline), TSC (solid outline) and EcF (dotted outline) See text for more details. Abbreviations: TE, echo time; mM, millimolar; ms, milliseconds; ROIs, regions of interest.