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. 2018 Mar 12;9:1028. doi: 10.1038/s41467-018-03411-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Box plots of gene expression according to genotype and Kaplan–Meier plots of disease-specific survival according to levels of expression for FADD (11q13), CDCA7 (2q31.1), ZFP36L1 (14q24.1) and MRPL34 (19p13.1). a Levels of expression of FADD are associated with 11q13.1-rs3903072 genotype in all cancers (P = 0.04) and ER+ cancers (P = 0.01); b in ER+ cancers, levels of expression of FADD are also associated with disease-specific survival (DSS) (c) excluding samples with copy-number gains strengthened the eQTL association in ER+ cancers (P = 0.004) (d) but attenuated the association with DSS. e, g, i Levels of expression of CDCA7, ZFP36L1 and MRPL34 are associated with 2q31.1-rs1550623 genotype in all cancers (P = 0.007), 14q24.1-rs2588809 genotype in ER+ cancers (P = 0.004) and 19p13.1-rs8170 in all cancers (P = 0.001) and ER+ cancers (P = 0.01), respectively. f, h, j In ER+ cancers, levels of expression of all three genes are associated with DSS