Table 4.
Six CHi-C putative target genes for which there was orthogonal support for at least two additional data sources
| Locus | SNP | Gene | eQTL Pall | eQTL PER+ | DSS PER+ | 727 cancer genes source |
|---|---|---|---|---|---|---|
| 2q31.1 | rs1550623 | CDCA7 | 0.007 (0.09) | 0.51 (0.67) | 4 × 10−7 | |
| 11q13.1 | rs3903072 | FADD | 0.04 (0.28) | 0.01* (0.17) | 0.0009 | Cancer related genes panel |
| 12q24.21 | rs1292011 | TBX3 | 0.28 (0.50) | 0.21 (0.52) | 0.012 | Cancer gene census |
| 14q13.3 | rs2236007 | PAX9 | 0.003 (0.07) | 0.05 (0.32) | 0.20 | Cancer related genes panel |
| 14q24.1 | rs2588809 | ZFP36L1 | 0.08 (0.38) | 0.004 (0.09) | 0.09 | Identified in Nik-Zainal et al 2016 |
| 19p13.11 | rs8170 | MRPL34 | 0.001 (0.06) | 0.01 (0.17) | 0.004 |
eQTL P values in parenthesis are FDR adjusted, * excluding 119 ER+ cancers with copy-number gains at FADD, P = 0.004