Skip to main content
. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Br J Haematol. 2017 Dec 3;180(1):134–146. doi: 10.1111/bjh.15011

Figure 3. Associations between targeted variants in the alpha-globin gene, HbF-promoting loci and APOL1, with painful acute VOC episodes or hospitalisation rates.

Figure 3

(A) Box and whisker plots showing the association of 3.7 alpha-globin gene deletions with vaso-occlusive crisis (VOC) (p = 0.002); a similar association was also reported with the hospitalisation rates (p = 0.02). (B) and (C) Box and whisker plots showing the associations of HbF- promoting loci variant with the hospitalisation rates: HBS1L-MYB-rs28384513 (p = 0.01); BCL11A-rs4671393 (p = 0.026); BCL11A-rs4671393 was also positively associated with VOC (p = 0.017), while HBS1L-MYB-rs28384513 was borderline with VOC (p = 0.057). (D) Box and whisker plots showing the association of APOL1 G1/G2 risk alleles with hospitalisation rates (p = 0.048); APOL1-rs71785313 (G2) was borderline with the hospitalisation rates (p = 0.059). Conventions are as per Figure 1.