Fig. 1. Structure of the 15 pedigrees examined in our study.

Males are indicated with squares, females with circles, and psychiatric diagnoses are shown by dark shading (full shading = bipolar disorder type I (BD-I), right shading = bipolar disorder type II (BD-II, left shading = recurrent unipolar depression (RUD), bottom shading = schizoaffective disorder-manic type (SZMA), unshaded = unaffected, u = unknown). Individuals included in the exome study are indicated by single asterisks, and subjects with both WES and CytoScanHD array data are indicated by double asterisks. All subjects with DNA available are underlined, and subjects with chip-based genotype data from which multidimensional scaling analysis and polygenic risk scores were generated are indicated with a second underline