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. 2018 Mar 12;8:4375. doi: 10.1038/s41598-018-22545-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The current density distribution of different electrode design using the voltage-control stimulation (−0.6 V). (A) The current density surface plot for each microelectrode design. Both the maximum and the average current density across the electrode surface was highest for the fractal design followed by serpentine II, serpentine I, and circular electrode. (B) Average current density as a function of distance away from each electrode center. (C) The total delivered current on hemispheric boundaries. (D) Simulated impedance Bode plot of each microelectrode design.