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. 2018 Mar 12;9(3):395. doi: 10.1038/s41419-018-0431-2

Fig. 4. miR-27a agomir inhibits the growth of cervical cancer xenografts in vivo.

Fig. 4

Mice harboring subcutaneous tumors derived from HeLa cells received intratumoral injection of PBS, agomir NC, or miR-27a agomir (N = 7/group). a The tumor size in the agomir group is significantly smaller than the NC group and the PBS group (23 days after inoculation). b The curves of relative tumor volume show a significantly slower tumor growth in the agomir group compared with controls. c HE staining and immunohistochemical detection of TGF-βRI, SMAD2, SMAD3, p-SMAD3, and Ki-67 in the xenografts (bar, 200 µm). d–h Quantification of the immunohistochemistry results. ***P < 0.001