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. 2018 Mar 12;8:4356. doi: 10.1038/s41598-018-21603-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Regional association signals of 3p14.2 locus. 4 Mb region around the most significant association, rs1554600 in 3p14.2 locus is displayed using imputed data. Variant with the most significant association (rs1554600) is indicated in purple diamond. Purple line indicates the genetic recombination rate (cM/Mb). SNPs in linkage disequilibrium with rs1554600 are shown in color gradient indicating r2 levels (hg19, 1KGP, Nov 2014, EUR).