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. 2018 Mar 12;8:4337. doi: 10.1038/s41598-018-22705-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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M-opsin/S-opsin expression ratios pre- and post-treatment in the retina of T4 treated animals. The opsin expression data for each eye were normalised by calculating the M-opsin/S-opsin expression ratio to control for different baseline expression levels in each eye (pre- and post-treatment). This allows comparison of relative differences between M- and S-opsin expression between both eyes, an alternative measure for changes in M-opsin expression levels. A significant increase was found in pooled data and after exclusion of animals older than 1,000 days (young), indicating that M-opsin expression is increased at a higher degree than S-opsin expression (two-tailed paired t-test). The effect in pooled data is lower (p = 0.046, n = 5) compared to young data (p = 0.028, n = 3). Data are presented as median ± interquartile range. *p < 0.05.