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. 2018 Jan 16;17(2):e12722. doi: 10.1111/acel.12722

Figure 1.

Figure 1

Design and working mechanism of senescence chip. (a) Illustration of two types of chips: (i) a chip with a 3D filter array and a cell trap array for capture and single‐cell analysis of senescent cells in blood; and (ii) a chip with a 3D filter array connected with a tubing at the outlet for removal of senescent cells from blood. Zoom‐in regions show schematic separation and trapping of RBC, WBC, and senescent cells, along with two types of pillar shapes A and B. (b) Mechanism of size‐based cell separation with a 3D filter array: (i) the top view of the filters with force analysis on the x and y directions; (ii) the side view of the filters on the x and z directions; and (iii) the perspective view of the filters on the x, y, and z directions. (c) Images of the experimental setup and operation: (i) an actual‐size image of a senescence chip relative to a US dime; (ii) the experimental setup showing tubing connections and pumps; and (iii) a senescence chip in operation of processing whole blood samples. Scale bar represents 5 mm in (c‐iii). RBC: red blood cell; WBC: white blood cell