Table 1.
Demographic characteristics of examined cohort.
| Examined (40) | Control (36) | Difference and significance | ||||
|---|---|---|---|---|---|---|
| Age (yrs., mean ± SD) | 47.88 ± 6.07 | 47.07 ± 6.68 | NS | |||
| Sex (male/female) | 22/18 | 16/14 | NS | |||
| Body mass index (BMI, kg/m2, mean ± SD) | 32.04 ± 6.67 | 22.18 ± 4.43 | p < 0.001 | |||
| Diabetes type 2 (yes/no) | 12/28 | 9/27 | NS | |||
| Hypertension (yes/no) | 32/8 | 16/20 |
p < 0.0001 Spearman correlation NAFLD + and hypertension, p < 0.0001 |
|||
| HDL/LDL ratio (mean ± SE) | 4.49 ± 0.23 | 2.94 ± 0.18 | p < 0.0001 | |||
| Status according to BMI: | ||||||
| Normal | 5 | 21 | p = 0.000028 | |||
| Overweight | 15 | 11 | ||||
| Obese | 20 | 4 | ||||
| Metabolic syndrome (yes/no) | 34/6 | 8/28 | Chi square, p < 0.00001 |
|||
| MoCA score (mean ± SD) | 24.07 ± 3.18 | 27.17 ± 2.35 | p < 0.001 | |||
| Total brain volume (cm3, mean ± SD) | 1388 ± 127.98 | 1417 ± 191.83 | NS | |||
| Gray matter volume (gmw in cm3 mean ± SD) | 405 ± 37.42 | 414 ± 56.09 | NS | |||
| White matter volume (wmw, in cm3 mean ± SD) | 338 ± 31.21 | 344 ± 46.83 | NS | |||
| Lateral ventricle volume, right/left (lvlr, lvll, in cm3 mean ± SD) | 5.97 ± 0.61 | 6.07 ± 0.62 | 5.64 ± 0.37 | 5.63 ± 0.37 | p = 0.009∗ | p < 0.001∗ |
| AST (U/l, mean ± SE) | 39.97 ± 2.61 | 24.03 ±3.26 | p < 0.001 | |||
| ALT (U/l mean ± SE) | 39.11 ± 2.86 | 36.71 ± 3.5 | NS | |||
| AST/ALT ratio (mean ± SE) | 1.13 ± 0.11 | 0.7 ± 0.06 | p = 0.01 | |||
| C-reactive protein (mg/l, mean ± SE) | 3.96 ± 0.45 | 3.52 ± 0.51 | NS | |||
| Fasting glycaemia (mmol/l, l mean ± SE) | 5.8 ± 0.19 | 3.71 ± 0.25 | p < 0.001 | |||
| Triglycerides (mmol/l, l mean ± SE) | 2.87 ± 0.18 | 1.71 ± 0.17 | p < 0.001 | |||
NS, not significant; SE, standard error. ∗Lateral ventricle volumes.