Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
The poisoned topoisomerase I-DNA complex is shown. The picture has been obtained using the software PyMol version 1.7 (Schrödinger, New York, NY, USA; http://www.pymol.org). The structure of the human topoisomerase is represented in white cartoon, while the DNA double helix is colored in orange (PDB code: 1K4T [121]). In the close-up, the intercalating event of the topoisomerase I poison topotecan (shown in yellow sticks) is reported.
