Table 3.

C-map hits for antimicrobial drugs, following MCF7 cells incubation with Bothrops jararaca venom.

C-Map Name	Dose (nM)	Score a	Up b	Down c	Drug Type
Primaquine	0.9 × 104	0.915	0.429	−0.517	Antiparasite (antimalarian activity)
Tanespimycin	0.1 × 104	0.814	0.161	−0.681	Antineoplastic Antibiotic
Cefalonium	0.9 × 104	0.775	0.250	−0.551	Antibiotic
Chlorhexidine	0.8 × 104	0.743	0.102	−0.667	Antibiotic
Novobiocin	1.0 × 105	0.737	0.056	−0.706	Antibiotic
Clioquinol	1.3 × 104	0.737	0.366	−0.396	Antifungal and antiprotozoal
Erythromycin	0.5 × 104	0.721	0.119	−0.627	Antibiotic
Tetracycline	0.8 × 104	0.710	0.211	−0.523	Antibiotic
Piperacillin	0.7 × 104	0.677	0.130	−0.571	Antibiotic
Ciclacillin	1.2 × 104	0.675	0.069	-0.629	Antibiotic
Halofantrine	0.7 × 104	0.675	0.146	−0.552	Antimalarial
Colistin	0.3 × 104	0.665	0.167	−0.521	Antibiotic
Cefoxitin	0.9 × 104	0.662	0.260	−0.424	Antibiotic
Minocycline	1.1 × 104	0.653	0.143	−0.532	Antibiotic
Azlocillin	0.8 × 104	0.649	0.099	−0.572	Antibiotic
Vancomycin	0.3 × 104	0.646	0.096	−0.572	Antibiotic
Sulfamonomethoxine	1.4 × 104	0.628	0.095	−0.555	Antibiotic
Dicloxacillin	0.8 × 104	0.627	0.097	−0.551	Antibiotic
Hycanthone	1.1 × 104	0.619	0.137	−0.503	Antischistosomal
Ribostamycin	0.7 × 104	0.605	0.126	−0.500	Antibiotic

^a Values between +1 and −1 represent the relative strength of a given signature in an instance from the total set of calculated instances; ^b values between +1 and −1 represent the absolute enrichment of an up tag-list in a given instance; ^c values between +1 and −1 represent the absolute enrichment of a down tag-list in a given instance.