Table 6.

C-map hits for anti-inflammatory drugs, following MCF7 cells incubation with Bothrops jararaca venom.

C-Map Name	Dose (nM)	Score a	Up b	Down c	Drug type
Sulindac	1.1 × 104	0.854	0.330	−0.553	Anti-inflammatory
Thalidomide	1.0 × 105	0.752	0.145	−0.632	Anti-inflammatory
Oxyphenbutazone	1.2 × 104	0.732	0.258	−0.499	Anti-inflammatory
Tenoxicam	1.2 × 104	0.710	0.107	−0.627	Anti-inflammatory
Epirizole	1.7 × 104	0.700	0.152	−0.572	Anti-inflammatory
Indoprofen	1.4 × 104	0.672	0.071	−0.624	Anti-inflammatory and analgesic
Budesonide	0.9 × 104	0.665	0.126	−0.562	Anti-inflammatory (Crohn’s Disease Treatment)
Methylprednisolone	1.1 × 104	0.663	0.142	−0.544	Anti-inflammatory
Mefenamic Acid	1.7 × 104	0.645	0.104	−0.563	Anti-inflammatory
Felbinac	1.9 × 104	0.642	0.151	−0.513	Anti-inflammatory (analgesic and antipyretic)
Acemetacin	1.0 × 104	0.627	0.116	−0.532	Anti-inflammatory

^a Values between +1 and −1 represent the relative strength of a given signature in an instance from the total set of calculated instances; ^b values between +1 and −1 represent the absolute enrichment of an up tag-list in a given instance; ^c values between +1 and −1 represent the absolute enrichment of a down tag-list in a given instance.