Table 4.
Characteristics of Trypanosoma cruzi–Infected Infants With and Without Clinical Signs Consistent With Congenital Chagas Disease
| Characteristic | Infants With Clinical Signs (N = 11) | Infants Without Clinical Signs (N = 27) | P Value |
|---|---|---|---|
| Median [IQR] maternal age | 20.8 [16.3,23.0] | 25.5 [22.0, 30.9] | .04 |
| Median [IQR] parity | 2 [1, 3] | 3 [2, 4] | .04 |
| Cord blood specimen | |||
| Micromethod positive | 4/11 (36.4) | 2/25 (8.0) | .06 |
| qPCR positive | 9/11 (81.8) | 15/24 (62.5) | .44 |
| Median [IQR] parasites/mL | 89 263 [5.4, 571552] | 37.9 [0, 10 175] | .04 |
| IgM TESA-blot positive | 8/11 (72.7) | 13/25 (52.0) | .30 |
| Umbilical cord tissue | |||
| qPCR positive | 9/11 (81.8) | 14/22 (63.4) | .43 |
| Median [IQR] parasites/mL | 8 59 119 [2133, >106] | 5.9 [0, 948 591] | .06 |
| 1-mo blood specimena | |||
| Micromethod positive | 3/7 (42.9) | 4/20 (20) | .33 |
| qPCR positive | 4/6 (66.7) | 15/19 (79.0) | .61 |
| Median [IQR] parasites/mL | 37 517 [0, 90 855] | 342 [1.1, 8720] | .39 |
| IgM TESA-blot positive | 2/7 (28.6) | 10/19 (52.6) | .39 |
| Cumulative 0 and 1 mo results | |||
| Micromethod positive | 7/11 (63.6) | 6/27 (22.2) | .03 |
| qPCR positive | 9/11 (81.8) | 23/27 (85.2) | 1.00 |
| IgM TESA-blot positive | 9/11 (81.8) | 19/26 (73.1) | .69 |
Abbreviations: IgM, immunoglobulin M; IQR, interquartile range; qPCR, quantitative polymerase chain reaction; TESA, trypomastigote excreted-secreted antigen.
aSix infants (4 with and 2 without clinical signs) treated before 1 month of age excluded from these analyses.