Table 1.
Summary of the Major Clinical and Laboratory Features of Severity Within the FEAST Study Sites
| Site | Mbale, Uganda | Soroti, Uganda | Lacor, Uganda | Kampala, Uganda | Kilifi, Kenya | Teule, Tanzania |
|---|---|---|---|---|---|---|
| No. | 1240 | 633 | 234 | 750 | 216 | 97 |
| Demographic features | ||||||
| Malaria endemicity | Holoendemic | Holoendemic | Hyperendemic | Hyperendemic | Mesoendemic | Mesoendemic |
| Male sex | 698 (56.3) | 340 (53.7) | 125 (53.4) | 394 (52.5) | 102 (47.2) | 46 (47.4) |
| Age, moa, median (IQR) | 25 (14–39) | 23 (14–36) | 27 (16–36) | 21 (12–39) | 26 (11–46) | 19 (12–39) |
| Clinical features of severity | ||||||
| Respiratory distress | 1222/1236 (99.0) | 495/630 (78.6) | 125 (53.4) | 514/745 (69.0) | 177 (82.0) | 77/96 (80.2) |
| Coma | 241/1239 (19.5) | 61/631 (9.7) | 30 (12.8) | 57 (7.6) | 57 (26.4) | 30 (31.0) |
| Jaundice | 759 (61.2) | 170/630 (27.0) | 28 (12.0) | 55/747 (7.4) | 1 (0.5) | 1 (1.0) |
| Dark urine | 180 (14.5) | 138/632 (21.8) | 27 (11.5) | 46/747 (6.2) | 1 (0.5) | 2 (2.0) |
| Laboratory data | ||||||
| Malaria positive | 699 (56.4) | 388 (61.3) | 171 (73.1) | 381 (51.0) | 88 (40.7) | 51 (52.6) |
| Hemoglobin level, g/dL, mean (SD) | 6.5 (3.1) | 6.5 (31) | 7.1 (2.9) | 8.1 (3.3) | 8.5(2.6) | 7.5 (3.1) |
| Severe anemiab | 639 (51.5) | 340 (53.7) | 96 (41.0) | 197/743 (26.5) | 34 (16.0) | 37 (38.0) |
| Hypoglycemiac | 46/1134 (4.1) | 19/618 (3.1) | 21/223 (9.4) | 29/710 (4.1) | 9/214 (4.2) | 12/95 (12.6) |
| Lactate >5 g/dL | 466/1135 (41.1) | 301/627 (48.0) | 90/210 (43.0) | 222/727 (30.5) | 55/214 (25.7) | 45/95 (47.4) |
| BUN >20 mmol/L | 131/605 (21.7) | 134/432 (31.0) | 51/159 (32.1) | 89/634 (14.0) | 25/189 (13.2) | 14/90 (15.6) |
| Outcome | ||||||
| Mortalityd | 115 (9.3) | 58 (9.2) | 38 (16.2) | 63 (8.4) | 21 (9.7) | 20 (20.6) |
Data are presented as No. (proportion) unless otherwise indicated. Denominators are indicated where data are missing.
Abbreviations: BUN, blood urea nitrogen; FEAST, Fluid Expansion as a Supportive Treatment; IQR, interquartile range; SD, standard deviation.
a
Completed months.
b
Hemoglobin level <5 g/dL.
c
Glucose <2.5 mmol/L.
d
At 48 hours postrandomization.