Table 3.

Relative Risk of Pulmonary Exacerbations in Children and Adults With Cystic Fibrosis

Parameter	Children (<18 y) RR (95% CI)	P Value	Adults (≥18 y) RR (95% CI)	P Value
Male sex	0.77 (.74–.81)	<.001	0.78 (.75–.82)	<.001
Race
White (ref.)	1.00 (ref.)		1.00 (ref.)
Other/unknown	1.03 (.88–1.20)	.7	0.96 (.84–1.08)	.5
African-American	0.92 (.84–1.01)	.08	0.87 (.80–.95)	.002
Age, per 5 y	1.55 (1.52–1.58)	<.001	0.95 (.95–.96)	<.001
Genotype
Heterozygous (ref.)	1.00 (ref.)		1.00 (ref.)
Homozygous	1.09 (1.04–1.15)	.001	1.08 (1.04–1.13)	<.001
Other/unknown	0.99 (.93–1.07)	.9	0.98 (.93–1.04)	.6
Insurance
None (ref.)	1.00 (ref.)		1.00 (ref.)
Government	2.91 (2.55–3.32)	<.001	3.00 (2.79–3.23)	<.001
Private only	1.62 (1.41–1.85)	<.001	1.64 (1.52–1.77)	<.001
Pancreatic sufficiency	1.37 (1.29–1.45)	<.001	1.44 (1.37–1.52)	<.001
% influenza positive, per 10%	1.02 (1.01–1.03)	<.001	1.02 (1.01–1.02)	<.001
% RSV positive, per 10%	1.05 (1.02–1.07)	<.001	1.01 (1.00–1.03)	.07

A multivariate Poisson regression model incorporating confounders was utilized for children and adults. Effects of temporal adjustments that were present in the multivariate model (quartic polynomial of year as well as sin and cos of 2π*year) are not shown.

Abbreviations: CI, confidence interval; RR, relative risk; RSV, respiratory syncytial virus.