Table 4.
Relative Risk of Pulmonary Exacerbations in Children and Adults With Cystic Fibrosis (Sensitivity Analysis)
| Parameter | Children (<18 y) RR (95% CI) |
P Value | Adults (≥18 y) RR (95% CI) |
P Value |
|---|---|---|---|---|
| Male sex | 0.82 (.79–.86) | <.001 | 0.75 (.72–.79) | <.001 |
| Race | ||||
| White (ref.) | 1.00 (ref.) | 1.00 (ref.) | ||
| Other/unknown | 0.89 (.75–1.06) | .2 | 0.91 (.78–1.06) | .2 |
| Black | 0.93 (.84–1.02) | .11 | 0.97 (.89–1.06) | .5 |
| Age, per 5 y | 1.22 (1.18–1.25) | <.001 | 0.91 (.90–.92) | <.001 |
| Genotype | ||||
| Heterozygous (ref.) | 1.00 (ref.) | 1.00 (ref.) | ||
| Homozygous | 1.02 (.98–1.07) | .3 | 1.07 (1.02–1.11) | .007 |
| Other/unknown | 0.91 (.86–.97) | .004 | 0.93 (.88–.99) | .03 |
| Insurance | ||||
| None (ref.) | 1.00 (ref.) | 1.00 (ref.) | ||
| Government | 2.45 (2.04–2.93) | <.001 | 2.61 (2.36–2.88) | <.001 |
| Private only | 1.81 (1.51–2.17) | <.001 | 1.80 (1.62–2.00) | <.001 |
| Median income, per $10000 | 0.99 (.97–1.00) | .02 | 1.00 (.99–1.01) | .5 |
| Pancreatic sufficiency | 1.56 (1.38–1.76) | <.001 | 1.20 (1.11–1.29) | <.001 |
| BMI, percentile, per 10% | 0.99 (.98–1.00) | .01 | 0.99 (.99–1.00) | .06 |
| FEV1% predicted, per 20% | 0.55 (.54–.56) | <.001 | 0.62 (.61–.63) | <.001 |
| % influenza positive, per 10% | 1.03 (1.02–1.04) | <.001 | 1.02 (1.01–1.03) | <.001 |
| % RSV positive, per 10% | 1.01 (.98–1.03) | .5 | 1.00 (.98–1.01) | .7 |
The above represents a multivariate Poisson regression model done as a sensitivity analysis for children and adults. Represents approximately 50% of total data due to missing data in additional covariates in the model (refer to Supplementary Methods). Effects of temporal adjustments that were present in the multivariate model (quartic polynomial of year as well as sin and cos of 2π*year) are not shown.
Abbreviations: BMI, body mass index; CI, confidence interval; FEV1, forced expiratory volume in 1 second; RR, relative risk; RSV, respiratory syncytial virus.