Table 1.
Demographic and Baseline Clinical Characteristics of Subjects Analyzed in the Modified Intent-to-Treat Analysis
| Characteristic | Azithromycin (500 mg; n = 106) | Levofloxacin (500 mg; n = 113) | Rifaximin (1650 mg) (n = 107) | Total (n = 326) |
|---|---|---|---|---|
| Age, median (IQR), y | 27 (23–33) | 28 (23–33) | 28 (23–34) | 27 (23–34) |
| Male, No. (%) | 100 (94.3) | 103 (91.2) | 97 (90.7) | 300 (92.0) |
| Enlisted rank, No. (%) | 86 (81.1) | 91 (80.5) | 83 (77.6) | 260 (77.6) |
| Race, No. (%) | ||||
| White | 89 (84.0) | 87 (77.0) | 93 (86.9) | 269 (82.5) |
| Black | 10 (9.4) | 16 (14.2) | 6 (5.6) | 32 (9.8) |
| Other | 7 (6.6) | 10 (8.8) | 8 (7.5) | 25 (7.7) |
| Service, No. (%) | ||||
| Army | 78 (73.6) | 73 (64.6) | 79 (73.8) | 230 (73.8) |
| Navy | 13 (12.3) | 18 (15.9) | 15 (14.0) | 46 (14.1) |
| Marines | 2 (1.9) | 2 (1.8) | 3 (2.8) | 7 (2.2) |
| Air Force | 9 (8.5) | 17 (15.0) | 7 (6.5) | 33 (10.0) |
| Other | 4 (3.8) | 3 (2.7) | 3 (2.8) | 10 (3.1) |
| Baseline clinical characteristicsa | ||||
| Maximum LLS in 24 hours (all cases), mean (SD), No. of stools | 6.3 (3.5) | 6.3 (4.2) | 6.3 (3.5) | 6.3 (3.7) |
| Subjects with ≥24 hours of diarrhea pretreatment, No. (%) | 46 (43.8) | 53 (47.3) | 48 (45.3) | 147 (45.5) |
| Maximum LLS in 24 hours (limited), mean (SD), No. of stoolsb | 6.8 (3.9) | 7.5 (5.0) | 6.5 (3.4) | 6.9 (4.2) |
| Diarrhea duration, mean (SD), h | 27 (22) | 27 (21) | 26 (19) | 27 (21) |
| Vomiting, No. (%) | 17 (16.2) | 20 (17.9) | 21 (19.8) | 58 (18.0) |
| Fever, No. (%) | 8 (7.6) | 11 (9.8) | 12 (11.3) | 31 (9.6) |
| Abdominal cramps, No. (%) | 76 (72.4) | 84 (75.0) | 80 (75.5) | 240 (74.3) |
| Fecal incontinence, No. (%) | 14 (13.3) | 13 (11.6) | 14 (13.2) | 41 (12.7) |
| Impact of illness on activity level/ability to function in primary duty assignment, No. (%) | ||||
| Normal | 28 (26.7) | 28 (25.0) | 20 (18.9) | 76 (23.5) |
| Decreased ≤50% | 51 (48.6) | 46 (41.1) | 52 (49.1) | 149 (46.1) |
| Decreased >50% | 24 (22.9) | 28 (25.0) | 30 (28.3) | 82 (25.4) |
| Complete inability to function | 2 (1.9) | 10 (8.9) | 4 (3.8) | 16 (5.0) |
Abbreviations; IQR, interquartile range; LLS, loose or liquid stools; SD, standard deviation.
aData missing for 3 subjects (1 from each treatment group).
bAnalysis limited to subjects with ≥24 hours of illness before presentation for treatment.