Table 1.

Assessment of Goals of Hepatitis B Virus Therapy After Drug Discontinuation

Cure Definition	Blood				Liver
	ALT	Hepatitis B virus DNA	Hepatitis B surface antigen	Anti-HBs	Covalently closed circular DNAa
Functional cure	Normal	Undetectable (quantitative PCR)	Undetectable	Detected	Present
Virological (complete) cure	Normal	Undetectable (qualitative PCR)	Undetectable	Detected	Undetectable

Abbreviation: ALT, alanine aminotransferase; Anti-HBs, antibody to Hepatitis B surface antigen; PCR, polymerase chain reaction.

^aAs detected in the liver. These assays are not currently commercially available or standardized.