Table 3.
Currently Used Virologic and Host Markers and Targets
| Assay | Specimen | Target | Reference |
|---|---|---|---|
| Virologic markers | |||
| HBV DNA (q, non-q) | Blood | Viral replication | [5] |
| HBsAg (non-q) | blood | HBsAg gene expression | [5] |
| HBsAg (q) | Blood | HBsAg gene expression | [10] |
| HBeAg | Blood | HBeAg gene expression | [11] |
| Host markers | |||
| Anti-HBs (q/non-q) | Blood | Immune restoration | [30, 32] |
| Anti-HBc (q/non-q) IgM, IgG | Blood | Exposure to HBV | [33] |
| Standard liver tests | Blood | Liver function and inflammation | [5] |
| Imaging | Liver | Detection of hepatocellular carcinoma | [5] |
Abbreviations: anti-HBc, antibody to hepatitis B core antigen; anti-HBs, antibody to hepatitis B surface antigen; HBeAg, hepatitis B e antigen; HBsAg, hepatitis B surface antigen; HBV, hepatitis B virus; Ig, immunoglobulin; q, quantitative test; non-q, nonquantitative test.